A synthesis is presented of the known gammaridean and caprellid amphipod fauna of Moçambique south of 20°S. Material was collected by the University of Cape Town and the South African Museum, reference to specimens collected by the University of the Witwatersrand. Samples were taken at Morrumbene estuary, Inhaca Island, Jangamo reef, Maxixe, Lagoa Poelela, Ponta Zavora and by dredging to depths up to 135 m, a total of 65 species being recovered. One genus Janice, and three species, namely Gitanopsis mariae, Janice spinidactyla and Gammaropsis inhaca are described as new to science. Five others, namely Paragrubia vorax Chevreux, Photis kapapa Barnard, Lyssianassa cinghalensis (Stebbing), Monoliropus falcimanus Mayer and Maera serrata Schellenberg, are new records for southern Africa (here defined as Africa south of 20°S). Brief diagnoses, references and distributions are given for each species.